1. Biotransformation --------- changes a xenobiotic to a less toxic compound:
always; not always; seldom; never
2. Where are microsomes made:
brain, liver, kidney, laboratory,
3. The best known Phase I reactions involved the enzymes system known as:
CYP, MFO, P450, all of the above.
4. What routes of administration of a chemical will avoid the "first pass
effect?"
inhalation, oral, skin, a and c.
5. Which of the following is a reasonable ranking, from most reliable to least
reliable, of sources of technical data:
1. Scientific American magazine, Time magazine, A consultant's report sealed
by a PE, peer-reviewed journal article
2. TV show, internet magazine, textbook,
3. peer-reviewed journal, textbook, consultant's report, newspaper.
4. Fairbanks Daily News-Miner ( AP story), TV show,Scientific American magazine,
EPA website
6. A body growth with the ability to metastasize or invade into surrounding
tissues is known as a:
Benign tumor, Malignant tumor, Hyperplasia, Hypertrophy
7. The initial stage in carcinogenesis in which there is an alteration of the
DNA (mutation) is referred to as the:
Progression stage, Promotion stage, Initiation stage, Metastasis
8. Most chemicals that become adducts are chemically electophiles T/F
9. A "hematoma" is certainly: a carcinoma, a sarcoma, a tumor or swelling, benign.
10. A p53 gene is an example of:
An oncogene; A protooncogene; A tumor supressor gene; A P450 gene with 397 deletions.