Cancer Risks

Here each risk is expressed as a unitless decimal (or scientific notation) and we sum the risks. The pathway of the risk is indicate by the subscripts.

Risk dermal at site + Risk ingestion at site + Risk ingestion at home + Risk inhalation at home = Total Cancer Risk

The assumption is that, at the DNA level where the cancer causing mutations are, it does not matter by what route the chemicals entered the receptor. In the write up of your calculations, you want to keep the risk for each route separate, because later when the risk management decisions are made, you may only need to eliminate one route in order to bring the risk into acceptable levels.

Now suppose you had two chemicals at the site, PCP and chemical Z. When computing the total risk, you just add the risks due to chemical Z to those of PCP:

Risk PCP,dermal at site + Risk PCP, ingestion at site +Risk PCP, ingestion at home+ Risk PCP, inhalation at home +Risk Z, dermal at site + Risk Z, ingestion at site +Risk Z, ingestion at home+ Risk Z, inhalation at home = Total Risk

Unlike the example above where both PCP and Z have the same exposure routes, it is possible that the routes of Z are different. For example if Z was volatile as well, you might have Risk Z, inhalation of vapors at site which you would just add with the others. Certain chemicals cause cancer at certain sites, therefore the addition of the risk of chemicals may be conservative. It is certainly a lot easier, and is the standard assumption. If you did not want to add them, you would need a toxicologist to report that the chemical causes different types of cancer only at certain organs and that these are different as well.

Generally you summarize your risk calculations in a table that may look like this:

Current Situation (Baseline)
 Receptor   Pathway  Cancer Risk

Kids 
 

 PCP

Z
 Ingestion at home  5 x 10 -6  2 x 10 -8
 Inhalation at home   2 x 10 -6   1 x 10 -7
 Ingestion at site   2 x 10 -7   2 x 10 -7
 Direct dermal at site   4 x 10 -7   1 x 10 -7
Inhalation of vapors at site  N/A   2 x 10 -5

 Total Risk per Chemical

 8 x 10 -6  2 x 10 -5

 Total Risk

3 x 10 -5 

Note several things about the table.

In your report you would probably extend the table down for the other receptors in this current or baseline situation, or you might make a new table for each receptor. If you had 5 or 6 chemicals you might extend the table to the right, adding columns for each chemicals. Also, you may want to highlight or bold the risks that are above the acceptable level. Uh oh, now I got to tell you about acceptable risks. NEXT

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