Module 08

Closes 28 October

Submodule 8A

Hepatic Toxicology, S&B Chapter 10

1. Vocabulary, Hepatic: hepatic artery, bile salts, portal vein, hepatic vein, common bile duct, gall bladder, central vein, bile canaliculi, HDL, LDL, Chylomicrons, micelle, lipoprotein, necrosis, cholestasis, jaundice.
2. Know the basic scheme of liver function: blood flow, bile flow.
3. Understand the main functions of the hepatocyte.
4. Know the basic layout of the acinus
6. Why is the liver the principal site of rodent cancer is lab animals.
7. Describe the principal marker enzymes: SGOT, SGPT, LDH, AP (the function, not what the initials stand for.)

Submodule8B

Alcohol

Understand the basic kinetics of alcohol absorption, distribution, and elimination.
Discuss the three types of alcoholic liver disease

Submodule 8C

Renal Toxicology, S&B Chapter 11

8. Vocabulary, renal: cortex, medulla, nephron, glomerulus, proximal tubule, loop of Henle, reabsorption, secretion,creatinine
9. Know the General layout of the kidney and what it does.
10. Why is the kidney prone to attack by xenobiotics
11. Discuss the secretion and reabsorption of toxics from the urine.
Why is the kidney so often the target organ of xenobiotics

Submodule 8D

Risk Communications and Ethics

Understand when risk communications is needed, situations.
7 Basic principles
Not to use Comparative Risk Analysis
Be able to discuss Sandman's components of outrage
Be aware of the existence of codes of ethics
Become familiar with some of the principles common to professional codes of ethics.