Module 07 |
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Submodule 7A Cardiovascular Toxicology S&B Chapter 8 |
1. Vocabulary: Endothelium, polarization and depolarization,
arrhythmias, tachycardia, bradycardia, anastomoses, Atherosclerosis, plaques,
myocardial infarction, Ischemic heart disease, 2. Know the basic scheme of the flow of blood 3. Know the major blood components: chemicals and cell types. Where are blood cells made? 4. What is a red blood cell, and how does it carry oxygen? How is this affected by CO and nitrates? 5. What is Atherosclerosis and describe the "injury to endothelium hypotheses." 6. What are the risk factors in atherosclerotic disease? 7. What are some of the mechanisms by which a smoker might damage their heart and vascular system. 8. What are some of the main types of anemia and how might ingested chemical cause these? |
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Submodule 7B Neurotoxicology, S&B Chapter 9 |
1. Vocabulary: CNS and PNS, somatic and autonomic nervous
systems, neurons, glial cells, axon, dendrite, nerve, myelin, synapse, neurotransmitter. 2. Describe the "blood-brain barrier" and its limitations 3. Understand in a very general way excitatory transmission: membrane potential, voltage gated channels, sodium-potassium ions pumps, action potential, depolarization, repolarization, synaptic function, presynaptic, gap, postsynaptic, receptors 4. Describe the main types of neurotoxicity: neuronal damage, axonopathy, myelinopathy, transmission toxicity, and give examples of each. 5. What is the etiology of Minamata Disease? What types of medical problems did victims have? |
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Submodule 7C Benzene metabolism |
Review the complexities of the metabolism of a relatively simple compound and appreciate the different routes an metabolic products possible. Mechanisms of benzene's ability to cause leukemia. | |
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Submodule 7D Free Radicals |
Indicate the pathways from superoxide anion to hydroxyl radical and their implications for health. Recognize some of the protective mechanisms and their limitations. | |