Name: Module 1 Quiz

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Instructions: You'll need this for the first few questions: From the Consumer Product Safety Act Definitions (15 USC 30, 1261:) The next several questions apply "(h)(1) The term ''highly toxic'' means any substance which falls within any of the following categories: (a) Produces death within fourteen days in half or more than half of a group of ten or more laboratory white rats each weighing between two hundred and three hundred grams, at a single dose of fifty milligrams or less per kilogram of body weight, when orally administered; or (b) produces death within fourteen days in half or more than half of a group of ten or more laboratory white rats each weighing between two hundred and three hundred grams, when inhaled continuously for a period of one hour or less at an atmospheric concentration of two hundred parts per million by volume or less of gas or vapor or two milligrams per liter by volume or less of mist or dust, provided such concentration is likely to be encountered by man when the substance is used in any reasonably foreseeable manner; or (c) produces death within fourteen days in half or more than half of a group of ten or more rabbits tested in a dosage of two hundred milligrams or less per kilogram of body weight, when administered by continuous contact with the bare skin for twenty-four hours or less."

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Question 1 Multiple Choice (1 points)
Question: Read the definitions carefully. Are these chronic or acute tests?

Acute
Chronic
Neither
Both

Question 2 Multiple Choice (1 points)
Question: Suppose we test 10 rats under option A.a)"Produces death within
fourteen days in half or more than half of a group of ten or more laboratory white rats each weighing between two hundred and three hundred grams, at a single dose of fifty milligrams or less per kilogram of body weight, when orally administered" At exactly 50 milligrams per kilogram of body weight, exactly 5 rats die. We would then say, the _________ is 50 mg/kg.

Highest dose
CE10
CE50
LD50


Question 3 Multiple Choice (1 points)
Question: Continuing, suppose at a dose of 50 mg/kg none of the rats die, but 9 of them become ill. The 9 will not eat and continuously whimper. You would say 50 mg/kg is the ________ of the chemical.

EC50
EC90
LD50
90th quartile


Question 4 True False (1 points)
Question: In the last case with the 9 whimpering rats, would the Consumer Product Safety Act require you to label this chemical "highly toxic?" True/False:


Question 5 Multiple Choice (1 points)
Question: What are the three routes of exposure?

Oral, Dermal, Lingual
Rat, Mouse, Rabbit
Oral, Dermal, Inhalation
Rat, Rat, and Mouse


Question 6 Multiple Choice (1 points)
Question: The next several questions refer to the document on scented candles.
The author said, "The first step in assessing risk is identifying the chemical hazards associated with candle emissions." That's part of the first step, which we call:

Hazard Identification
Exposure-Response Assessment
Exposure Assessment
Risk Characterization


Question 7 Multiple Choice (1 points)
Question: the author identified three main chemical hazards:

wicks, fire, water
soot, benzene, lead
soot, lead, wire
soot and lead only


Question 8 Multiple Choice (1 points)
Question: The author worked at the dose-response for candle soot, but did not find any information. He then proposed to use information available from what to estimate the dose-response.

benzene
diesel exhaust
methyl ethyl ketone
none of the above


Question 9 Multiple Choice (1 points)
Question: The author notes: "Due to the lower air exchange rates in newer homes, the residence time of emissions were determined to continue for up to 10 hours after extinguishing a candle." Here he is working up a/an:

Exposure Assessment
LD50
EC50
Response Factor


Question 10 Multiple Choice (1 points)
Question: The author says, "The absence of consumer warnings concerning candle emissions and their potential health effects may contribute to exposure of susceptible individuals to respiratory inflammatory agents, carcinogens and teratogens. " Implying consumer warning labels should be put on candles. This issue belongs in:

Exposure Assessment
Dose-Response Evaluation
Risk Characterization
Risk Management.